Variant position: 393 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 408 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PIHERNLTLLLLLLQILGSA ITFSIRYQLVRLFYDV-------
Mouse PIHERNLTLLLLLLQVLSSA ATFSIRYQLVRLFYDV
Bovine PMHERNLTLLLLLLQVVGSA VTFSIRYQLVRLFYDV
Slime mold PLTERQLCVYLLIFQGLCSC VGFGIRYH--HLHHNP
Baker's yeast PMREDKLCNTILKLQFCIGI LALLGRHAIGAIIFGH
Fission yeast PMREDHLTICIMGLQLLTGI FGLIIRHFVAPLVYPE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 408 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
376 – 400 Helical; Name=Helix 10
385 – 385 L -> R. No significant effect on enzyme activity.
376 – 398
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3); VARIANT VAL-393;
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