Variant position: 944 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1627 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ITISGTEESEPSPAVTYIHG SGYCGDGIIQKDQGEQCDDMN
Mouse ITISGNEESEPSPAAIYTHG SGYCGDGVIQKDQGEECDDMN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
82 – 1627 Pappalysin-1
Complete cDNA sequence of the preproform of human pregnancy-associated plasma protein-A. Evidence for expression in the brain and induction by cAMP.
Haaning J.; Oxvig C.; Overgaard M.T.; Ebbesen P.; Kristensen T.; Sottrup-Jensen L.;
Eur. J. Biochem. 237:159-163(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; INDUCTION; VARIANT ARG-944;
Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA.
Kristensen T.; Oxvig C.; Sand O.; Moller N.P.H.; Sottrup-Jensen L.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-1627; PROTEIN SEQUENCE OF 82-98; 117-126; 210-224; 466-485; 507-519; 576-593; 609-621; 718-736; 742-754; 1006-1017; 1259-1273; 1369-1374; 1389-1398; 1490-1509; 1524-1533 AND 1537-1544; VARIANT ARG-944; TISSUE SPECIFICITY;
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