Variant position: 281 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 441 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SIDREKIAVIGHSFGGATVI QTLSEDQRFRCGIALDAWMFP
Mouse AIDETKIALMGHSFGGATVL QALSEDQRFRCGVALDPWMYP
Bovine SIDRDKIAIIGHSFGGATVI QTLSEDQRFRCGIALDAWMFP
Chicken SVDTSRIAVMGHSFGGATVI ESLSKEIRFRCGIALDAWMLP
Caenorhabditis elegans KLVMSSASVIGHSFGGATSL ASSAYTTDFQKAIVFDGWMYP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
22 – 441 Platelet-activating factor acetylhydrolase
273 – 273 Nucleophile
296 – 296 Charge relay system
273 – 273 S -> A. Loss of activity.
286 – 286 D -> A. Almost no activity.
286 – 286 D -> N. Diminishes activity.
296 – 296 D -> A. Loss of activity.
296 – 296 D -> N. Loss of activity.
274 – 285
Loss of activity of plasma platelet-activating factor acetylhydrolase due to a novel Gln281-->Arg mutation.
Yamada Y.; Yokota M.;
Biochem. Biophys. Res. Commun. 236:772-775(1997)
Cited for: VARIANT PAFAD ARG-281;
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