Variant position: 786 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 825 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PGGVPLEASLCPASLAPSGI SEKSKSSSSFHPAPGNAQSSS
Mouse PEGIPPEANLMSAPKTPSNL SGEGKG-------PGHSPVPS
Rat PGEMSQEANLTLAPRTPSNL SGVGKG-------PGHSPVPS
Pig SSGVPLEASLSPASLALLGV SREGKIPPCLQITPSNVQSSS
Horse PGGVPLEAGLSLASLGSLGL SEERKPSLFFQPAPGNAQSSS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
26 – 825 Interleukin-4 receptor subunit alpha
257 – 825 Cytoplasmic
228 – 825 Missing. In isoform 2.
Common polymorphisms in the coding part of the IL4-receptor gene.
Deichmann K.; Bardutzky J.; Forster J.; Heinzmann A.; Kuehr J.;
Biochem. Biophys. Res. Commun. 231:696-697(1997)
Cited for: VARIANTS VAL-75; ALA-400; ARG-431; LEU-436 AND PRO-786;
Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences.
Andrews R.P.; Burrell L.; Rosa-Rosa L.; Cunningham C.M.; Brzezinski J.L.; Bernstein J.A.; Khurana Hershey G.K.;
Clin. Immunol. 100:298-304(2001)
Cited for: VARIANT PRO-786;
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