Variant position: 449 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 492 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FLQGNVDSCQGDSGGPLVTS KNNIWWLIGDTSWGSGCAKAY
Mouse FLQGSVDSCQGDSGGPLVTL KNGIWWLIGDTSWGSGCAKAL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
256 – 492 Transmembrane protease serine 2 catalytic chain
106 – 492 Extracellular
256 – 489 Peptidase S1
441 – 441 Charge relay system
437 – 465
441 – 441 S -> A. Loss of activity.
No reference for the current variant in UniProtKB/Swiss-Prot.
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