Variant position: 135 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 256 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KLNDVLLIQLSSPANLSASV ATVQLPQQDQPVPHGTQCLAM
Mouse NLNDVLLLQLNRTASLGKEV AVASLPQQDQTLSQGTQCLAM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
28 – 248 Myeloblastin
28 – 248 Peptidase S1
118 – 118 Charge relay system
129 – 129 N-linked (GlcNAc...) asparagine
Wegener autoantigen and myeloblastin are encoded by a single mRNA.
Labbaye C.; Musette P.; Cayre Y.E.;
Proc. Natl. Acad. Sci. U.S.A. 88:9253-9256(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS ILE-119; THR-135 AND SER-136;
Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen.
Sturrock A.B.; Franklin K.F.; Rao G.; Marshall B.C.; Rebentisch M.B.; Lemons R.S.; Hoidal J.R.;
J. Biol. Chem. 267:21193-21199(1992)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-254; VARIANTS THR-135 AND SER-136;
Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells.
Bories D.; Raynal M.-C.; Solomon D.H.; Darzynkiewicz Z.; Cayre Y.E.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-256; VARIANTS ILE-119; THR-135 AND SER-136;
Wegener's autoantigen decoded.
Jenne D.E.; Tschopp J.; Luedemann J.; Utecht B.; Gross W.L.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-256; PROTEIN SEQUENCE OF 28-48; VARIANTS ILE-119; THR-135 AND SER-136; IDENTITY OF WEGENER'S AUTOANTIGEN WITH PR-3;
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