Variant position: 445 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 474 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GQAATPETPQPSPPGGSGSE PYKLLPGAVATIVKPLSAIPQ
Mouse GQAATPETPQPSPPSGSGSE SYKLLPGAITTIVKPPSAIPQ
Rat GQAATPETPQPSPPSGSGSE SYKLLPGAITTIVKPPSAIPQ
Xenopus laevis ---STPETPQPSPPAGSGAE QYKIVHGTIASINKQPTSIPQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 474 Hepatocyte nuclear factor 4-alpha
429 – 429 Phosphothreonine
432 – 432 Phosphothreonine
436 – 436 Phosphoserine
458 – 458 N6-acetyllysine
378 – 474 SPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI -> PCQAQEGRGWSGDSPGDRPHTVSSPLSSLASPLCRFGQVA. In isoform HNF4-Alpha-3 and isoform HNF4-Alpha-9.
Isolation and characterization of a third isoform of human hepatocyte nuclear factor 4.
Kritis A.A.; Argyrokastritis A.; Moschonas N.K.; Power S.; Katrakili N.; Zannis V.I.; Cereghini S.; Talianidis I.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HNF4-ALPHA-1; HNF4-ALPHA-2 AND HNF4-ALPHA-3); VARIANT SER-445;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.