Variant position: 575 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 610 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IPLVAGLSAAGLSLLTLAPF LLWLRKCLRK-AKKFVPASS-CQ
Mouse RPLVVALSAAGTSLLTSSSL LYLLMRYFRKKAKKFVPASS-
Rat RPLVVALSVAATSLLTLSSL IYVLKRFFWKKAKKFVPASS-
Pig IPLAMGLAAGGVSFMTSASF LLWLLKRLRKRAKKFVPSSS-
Bovine TPLAVGLSTAGVSLVTIPSF LFWLLKRLQKKAKKFSPASS-
Rabbit VPLAVGLSVSGTSFLTLTSF LLWFLKYFRKKAKKFVPASSR
Horse IPLTVGLSAAGTSLLTLASF LFWLLKRLRRKAKKFVPASS-
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS SER-21; ILE-31; ARG-149; PRO-257; LYS-295; GLN-421; TYR-468; SER-550 AND PHE-575;
DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis.
Wenzel K.; Ernst M.; Rohde K.; Baumann G.; Speer A.;
Hum. Genet. 97:15-20(1996)
Cited for: VARIANTS ARG-149 AND PHE-575;
Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
Halushka M.K.; Fan J.-B.; Bentley K.; Hsie L.; Shen N.; Weder A.; Cooper R.; Lipshutz R.; Chakravarti A.;
Nat. Genet. 22:239-247(1999)
Cited for: VARIANTS ARG-149; TYR-468 AND PHE-575;
Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort.
Sass C.; Pallaud C.; Zannad F.; Visvikis S.;
Hum. Genet. 107:58-61(2000)
Cited for: VARIANT PHE-575;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.