UniProtKB/Swiss-Prot P19827: Variant p.Ser263Thr

Inter-alpha-trypsin inhibitor heavy chain H1
Gene: ITIH1
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Variant information Variant position:

263 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant:

LB/B The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Serine (S) to Threonine (T) at position 263 (S263T, p.Ser263Thr). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties:

Change from small size and polar (S) to medium size and polar (T) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score:

1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page
Polymorphism:

There are 3 common alleles; ITIH1*1 with Glu-585/Gln-595, ITIH1*2 with Val-585/Arg-595 and ITIH1*3 with Glu-585/Arg-595. Additional information on the polymorphism described.
Other resources:

Links to websites of interest for the variant.

Variant rs1042777 [ dbSNP | Ensembl ]

Sequence information Variant position:

263 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length:

911 The length of the canonical sequence.
Location on the sequence:

SCPTCSTSLLNGHFKVTYDV S RDKICDLLVANNHFAHFFAP The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         SCPTCSTSLLNGHFKVTYDVSRDKICDLLVANNHFAHFFAP

Mouse                         SCPTCSTSLLNGEFKVTYDVNRDKLCDLLVANNYFTHFFAP

Pig                           SCSTCSTTLLNGDFKVTYDVNREKLCDLLVANNYFAHFFAP

Bovine                        TCPTCSTTLLNGDFKVTYDVNRDDACDLLVANNYFAHFFAP

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	35 – 672	Inter-alpha-trypsin inhibitor heavy chain H1
Alternative sequence	1 – 288	Missing. In isoform 3.

Literature citations
Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1.
Diarra-Mehrpour M.; Bourguignon J.; Bost F.; Sesboue R.; Muschio F.; Sarafan N.; Martin J.-P.;
Biochim. Biophys. Acta 1132:114-118(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS THR-263; VAL-585 AND ARG-595;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.