Sequence information
Variant position: 532 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 594 The length of the canonical sequence.
Location on the sequence:
NVCFWYIPQSLRGVPDSPQR
R EKLHKVAPKIKALMMESGTT
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NVCFWYIPQSLRGVPDSPQRR EKLHKVAPKIKALMMESGTT
NVCFWYIPQSLRGIPDSPERR EKLHRVAPKIKALMMESGTT
Chimpanzee NVCFWYIPQSLRGVPDSPQRR EKLHKVAPKIKALMMESGTT
Mouse NVCFWYIPQSLRGVPDSPERR EKLHRVAPKIKALMMESGTT
Rat NVCFWYIPQSLRGVPDSPERR EKLHRVAPKIKALMMESGTT
Pig NVCFWYIPQSLRGVPDSPERR EKLHRVAPKIKALMMESGTT
Bovine NVCFWYIPQSLRGVPDSPERR EKLHRVAPKIKALMMESGTT
Cat NVCFWYIPQSLRGIPDSPERR EKLHRVAPKIKALMMESGTT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 594
Glutamate decarboxylase 1
Alternative sequence
225 – 594
Missing. In isoform 3.
Alternative sequence
426 – 594
Missing. In isoform 4.
Helix
529 – 549
Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS LEU-228 AND GLN-532;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.