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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P08833: Variant p.Val183Ile

Insulin-like growth factor-binding protein 1
Gene: IGFBP1
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Variant information Variant position: help 183
Type of variant: help LB/B
Residue change: help From Valine (V) to Isoleucine (I) at position 183 (V183I, p.Val183Ile).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 3
Other resources: help


Sequence information Variant position: help 183
Protein sequence length: help 259
Location on the sequence: help ALHVTNIKKWKEPCRIELYR V VESLAKAQETSGEEISKFYL
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 26 – 259 Insulin-like growth factor-binding protein 1
Domain 173 – 251 Thyroglobulin type-1
Modified residue 193 – 193 Phosphothreonine; by FAM20C
Modified residue 194 – 194 Phosphoserine; by FAM20C
Modified residue 199 – 199 Phosphoserine; by FAM20C
Disulfide bond 176 – 206
Helix 175 – 193



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ILE-183 AND MET-253;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.