Home  |  Contact

UniProtKB/Swiss-Prot Q04941: Variant p.Ala91Ser

Proteolipid protein 2
Gene: PLP2
Variant information

Variant position:  91
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Alanine (A) to Serine (S) at position 91 (A91S, p.Ala91Ser).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from small size and hydrophobic (A) to small size and polar (S)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  91
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  152
The length of the canonical sequence.

Location on the sequence:   LHTKIPFINWPWSDFFRTLI  A AILYLITSIVVLVERGNHSK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         LHTKIPFINWPWSDFFRTLIAAILYLITSIVVLVE-RGNHSK-------------

Mouse                         LHSKISFINWPWTDFFRSLIATILYLITSIVVLVE-GRGSS

Rat                           LHSKISFINWPWTDFFRSLIAAILYLITSIVVLVE-GRGSS

Bovine                        LHTKIQIINWPWSDFFRTLVAAILYLITSIVVLVE-RGNGS

Rabbit                        LHTRAPFINWPWSDFFRTLIAAILYLITSIFVLVE-RGNHS

Baker's yeast                 IPANRAIENYPESNCPTLIVYYRGEVIKNMITLLELGGNNS

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 152 Proteolipid protein 2
Transmembrane 85 – 105 Helical
Domain 19 – 137 MARVEL
Glycosylation 108 – 108 N-linked (GlcNAc...) asparagine


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.