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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P05090: Variant p.Thr178Lys

Apolipoprotein D
Gene: APOD
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Variant information Variant position: help 178
Type of variant: help LB/B
Residue change: help From Threonine (T) to Lysine (K) at position 178 (T178K, p.Thr178Lys).
Physico-chemical properties: help Change from medium size and polar (T) to large size and basic (K)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 178
Protein sequence length: help 189
Location on the sequence: help ETVDSLKNILTSNNIDVKKM T VTDQVNCPKLS
Residue conservation: help 
Human                         ETVDSLKNILTSNNIDVKKMTVTDQVNCPKLS

Mouse                         ETITYLKDILTSNGIDIEKMTTTDQANCPDFL

Rat                           ETITYLKYILTSNDIDIAKITTKDQANCPDFL

Bovine                        ETVTYLKDILTSNNIEVEKMTITDQVNCPESM

Rabbit                        ETVTYLKDILTANNIDIEKMTVTDQVNCPEF-
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 21 – 189 Apolipoprotein D
Disulfide bond 61 – 185



Literature citations
Characterization of single-nucleotide polymorphisms in coding regions of human genes.
Cargill M.; Altshuler D.; Ireland J.; Sklar P.; Ardlie K.; Patil N.; Shaw N.; Lane C.R.; Lim E.P.; Kalyanaraman N.; Nemesh J.; Ziaugra L.; Friedland L.; Rolfe A.; Warrington J.; Lipshutz R.; Daley G.Q.; Lander E.S.;
Nat. Genet. 22:231-238(1999)
Cited for: VARIANTS SER-15; LEU-115 AND LYS-178;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.