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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q00403: Variant p.Pro19Ser

Transcription initiation factor IIB
Gene: GTF2B
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Variant information Variant position: help 19 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Proline (P) to Serine (S) at position 19 (P19S, p.Pro19Ser). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and hydrophobic (P) to small size and polar (S) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 19 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 316 The length of the canonical sequence.
Location on the sequence: help MASTSRLDALPRVTCPNH P DAILVEDYRAGDMICPECGL The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         MASTSRLDALP---------RVTCPNHP--DAILVEDYRAGDMICPECGL

Mouse                         MASTSRLDALP---------RVTCPNHP--DAILVEDYR

Rat                           MASTSRLDALP---------RVTCPNHP--DAILVEDYR

Bovine                        MASTSRLDALP---------RVTCPNHP--DAILVEDYR

Xenopus laevis                MASTSRIDALP---------KVTCPNHP--DALLVEDYR

Caenorhabditis elegans        MSA-----------------PVQCPIHP--DVHLIEDHR

Drosophila                    MASTSRLDNN----------KVCCYAHP--ESPLIEDYR

Slime mold                    MLSAAP-KPTPQNKKQSFYNKLWCMVCRIQDPDIIEDYA

Baker's yeast                 MMTRESIDKRAGRRGPNLNIVLTCPECKVYPPKIVERFS

Fission yeast                 -MNAPSFTGLP---TSMLSVKMICSECREDPPNLVEEFS

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 316 Transcription initiation factor IIB
Zinc finger 11 – 42 TFIIB-type
Binding site 15 – 15
Binding site 18 – 18
Binding site 34 – 34
Binding site 37 – 37
Mutagenesis 37 – 37 C -> S. Does not inhibit interaction with TBP. Inhibits the recruitment of RNA polymerase II into the initiation complex.
Beta strand 18 – 20



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.