Variant position: 64 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 219 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LREEIHKDLLVTGAYEISDQ SGGAG-GLRSHLKITDSAGHIL
Mouse LREEIHKDLLVTGAYEITDQ SGGAG-GLRTHLKITDSAGHI
Rat LREEIHKDLLVTGAYEITDQ SGGAG-GLRTHLKITDSAGHI
Bovine LREEIHKDLLVTGAYEITDQ SGGAG-GLRTHLKITDSAGHI
Rabbit LREEIHKDLLVTGAYEITDQ SGGAG-GLRTHLKITDSAGHI
Drosophila LKEDIQANQLVMGEFEVSDV PGQI-----IDYIARDTKGHI
Slime mold IYEEIGVDLSFTAMFQVIQ- -GGFND---IDFTIISPDKRI
Baker's yeast IRDFVTEGQLVVADIH-SD- -GSVGDGQKLNLFVRDSVGNE
Fission yeast LREYVGEKNLVIVNLK-TT- -GNMGDGQTLSMMITDSSGNT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
32 – 219 Transmembrane emp24 domain-containing protein 10
32 – 185 Lumenal
41 – 193 GOLD
1 – 142 Required for interaction with STX17
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.