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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P41143: Variant p.Cys27Phe

Delta-type opioid receptor
Gene: OPRD1
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Variant information Variant position: help 27 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Cysteine (C) to Phenylalanine (F) at position 27 (C27F, p.Cys27Phe). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and polar (C) to large size and aromatic (F) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help Improved maturation and increased expression at the cell surface. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 27 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 372 The length of the canonical sequence.
Location on the sequence: help AGAELQPPLFANASDAYPSA C PSAGANASGPPGARSASSLA The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         AGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLA

Mouse                         ARAELQSSPLVNLSDAFPSAFPSAGANASGSPGARSASSLA

Rat                           ARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLA

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 372 Delta-type opioid receptor
Topological domain 1 – 47 Extracellular
Glycosylation 18 – 18 N-linked (GlcNAc...) asparagine
Glycosylation 33 – 33 N-linked (GlcNAc...) asparagine



Literature citations
Identification of a human delta opioid receptor: cloning and expression.
Knapp R.J.; Malatynska E.; Fang L.; Li X.; Babin E.; Nguyen M.; Santoro G.; Varga E.V.; Hruby V.J.; Roeske W.R.; Yamamura H.I.;
Life Sci. 54:PL463-PL469(1994)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; SUBCELLULAR LOCATION; VARIANT PHE-27; Isolation of cDNA coding for human opioid receptor, delta 1 (OPRD1).
Kaighin V.A.; Martin A.L.; Aronstam R.S.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT PHE-27; Cys-27 variant of human delta-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization.
Leskela T.T.; Lackman J.J.; Vierimaa M.M.; Kobayashi H.; Bouvier M.; Petaja-Repo U.E.;
J. Biol. Chem. 287:5008-5020(2012)
Cited for: FUNCTION; SUBCELLULAR LOCATION; GLYCOSYLATION; SUBUNIT; CHARACTERIZATION OF VARIANT PHE-27; Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence.
Gelernter J.; Kranzler H.R.;
Hum. Genet. 107:86-88(2000)
Cited for: VARIANT PHE-27;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.