Variant position: 798 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1279 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DIECLASDGMLLVSC---CLAGH VCVWDAQTGDCLTRIPRPGRQ
Mouse DIECLASDGMLLVSC---CLAGQ VCVWDAQTGDCLTRIPRP
Rat DIECLASDGMLLVSC---CLAGQ VCVWDAQTGDCLTRIPRP
Pig DIECLASDGMLLVSC---CLAGH VCVWDAQTGDCLTRIPHP
Bovine DIECLASDGMLLVSC---CLAGH VCVWDAQTGDCLTRIPHP
Xenopus laevis DIECLASDKMLLVSC---CLAGQ IRVWDAQSGDCLTIIPKP
Fission yeast SL--FSKDTLFILNVESPCLMLQ HS-YHCKPNSKLNVFWMP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1279 Sterol regulatory element-binding protein cleavage-activating protein
731 – 1279 Cytoplasmic
771 – 811 WD 1
731 – 1279 Interaction with SREBF2
476 – 983 Missing. In isoform 3.
817 – 817 Missing. In isoform 2 and isoform 4.
A common Ile796Val polymorphism of the human SREBP cleavage-activating protein (SCAP) gene.
Iwaki K.; Nakajima T.; Ota N.; Emi M.;
J. Hum. Genet. 44:421-422(1999)
Cited for: VARIANT ILE-798;
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