Sequence information
Variant position: 280 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 445 The length of the canonical sequence.
Location on the sequence:
GCWQKGHGEAMPLHRYGVGE
A AVGAEAGEATLGGGGGGGSV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GCWQKGHGEAMPLHRYGVGEA AVGAEAGEATLGGGGGGGSV
Mouse GCWPKGHGEAMPLHRYGVGEA GPGVETGEAGLGGGSGGGAA
Rat GCWPKGHGEAMPLHRYGVGEA GPGVEAGEAALGGGSGGGAA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 445
Histamine H3 receptor
Topological domain
218 – 359
Cytoplasmic
Alternative sequence
197 – 315
Missing. In isoform 5.
Alternative sequence
227 – 342
Missing. In isoform 6.
Alternative sequence
274 – 353
Missing. In isoform 3.
Literature citations
Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations.
Wiedemann P.; Boenisch H.; Oerters F.; Bruess M.;
J. Neural Transm. 109:443-453(2002)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT VAL-280;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.