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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P16662: Variant p.Tyr268His

UDP-glucuronosyltransferase 2B7
Gene: UGT2B7
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Variant information Variant position: help 268 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Tyrosine (Y) to Histidine (H) at position 268 (Y268H, p.Tyr268His). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and aromatic (Y) to medium size and polar (H) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Polymorphism: help 2 alleles have been identified: UGT2B7*1 (His-268) and UGT2B7*2 (Tyr-268). The sequence shown is that of allele UGT2B7*2. Additional information on the polymorphism described.
Variant description: help In allele UGT2B7*1. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 268 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 529 The length of the canonical sequence.
Location on the sequence: help ETMGKADVWLIRNSWNFQFP Y PLLPNVDFVGGLHCKPAKPL The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         ETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPL

Rat                           DTMKKAEIWLIRSYWDLEFPRPSLPNIEFVGGLHCQPAKPL

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 24 – 529 UDP-glucuronosyltransferase 2B7



Literature citations
Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates.
Ritter J.K.; Sheen Y.Y.; Owens I.S.;
J. Biol. Chem. 265:7900-7906(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT HIS-268; Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance.
Bhasker C.R.; McKinnon W.; Stone A.; Lo A.C.; Kubota T.; Ishizaki T.; Miners J.O.;
Pharmacogenetics 10:679-685(2000)
Cited for: VARIANT HIS-268;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.