Sequence information
Variant position: 276 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 367 The length of the canonical sequence.
Location on the sequence:
SSQPQPEGANEAVPTPVVDP
D APPSPPLGAPGLPPAGSPPD
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SSQPQPEGANEAVP-----TPVVDPD APPSPPLGAPGLPPAGSPPD
Chimpanzee TSQPQPEGANETVP-----TPVVDPD APPSPPLGAPGLPPA
Mouse ----QPANANAVGP-----VPTANAA LPADP----P-ASVV
Rat ----QPANANPAGP-----APTVGQA APVAPPAGPP-ESVV
Bovine IPQPQPDGAEAEAP-----SAVPDAA GPTPSAAGPPVASVV
Sheep IPQPQPEGAEAGAPSAVPDAAVPDAA VPAPSAAGLPVGSVV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
19 – 300
Alpha-2-HS-glycoprotein chain A
Region
255 – 298
Disordered
Compositional bias
272 – 293
Pro residues
Glycosylation
270 – 270
O-linked (GalNAc...) threonine
Glycosylation
280 – 280
O-linked (GalNAc...) serine
Glycosylation
293 – 293
O-linked (GalNAc...) serine
Disulfide bond
32 – 358
Interchain (between A and B chains)
Literature citations
Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene.
Osawa M.; Yuasa I.; Kitano T.; Henke J.; Kaneko M.; Udono T.; Saitou N.; Umetsu K.;
Ann. Hum. Genet. 65:27-34(2001)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS THR-248; THR-256; ASN-276 AND CYS-317;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.