Sequence information
Variant position: 317 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 367 The length of the canonical sequence.
Location on the sequence:
SHVLLAAPPGHQLHRAHYDL
R HTFMGVVSLGSPSGEVSHPR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SHVLLAAPPGHQLHRAHYDLR HTFMGVVSLGSPSGEVSHPR
Chimpanzee SHVLLAAPPGHQLHWAHYDLR HTFMGVVSLGSPSGEASHPR
Mouse ----VVVPRGLSDHRTYHDLR HAFSPVASVESASGETLH--
Rat ----VAVPLGLPDHRTHHDLR HAFSPVASVESASGEVLH--
Bovine ----SVVAVPLPLHRAHYDLR HTFSGVASVESSSGEAFHVG
Sheep ----SVVAVPLPLHRAHYDLR HTFSGVASVESASGEAFHVG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Propeptide
301 – 340
Connecting peptide
Modified residue
319 – 319
Phosphothreonine; by FAM20C
Modified residue
325 – 325
Phosphoserine; by FAM20C
Modified residue
328 – 328
Phosphoserine; by FAM20C
Modified residue
330 – 330
Phosphoserine; by FAM20C
Disulfide bond
32 – 358
Interchain (between A and B chains)
Literature citations
Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene.
Osawa M.; Yuasa I.; Kitano T.; Henke J.; Kaneko M.; Udono T.; Saitou N.; Umetsu K.;
Ann. Hum. Genet. 65:27-34(2001)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS THR-248; THR-256; ASN-276 AND CYS-317;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.