Variant position: 475 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 750 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SIEGNYTLRVDCTPLMYSLV HNLTKELKSPDEGFEGKSLYE
Mouse SIEGNYTLRVDCTPLMYSLV YNLTKELQSPDEGFEGKSLYD
Rat SIEGNYTLRVDCTPLMHSLV YNLTKELPSPDEGFEGKSLYD
Pig SIEGNYTLRVDCTPLMYSLV YNLTKELQSPDEGFEGKSLFE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 750 Glutamate carboxypeptidase 2
44 – 750 Extracellular
274 – 587 NAALADase
459 – 459 N-linked (GlcNAc...) asparagine
476 – 476 N-linked (GlcNAc...) asparagine
1 – 585 Missing. In isoform PSMA-3.
244 – 750 Missing. In isoform PSMA-4.
459 – 459 N -> A. Loss of glycosylation. Reduces enzyme activity.
476 – 476 N -> A. Loss of glycosylation. Reduces enzyme activity.
471 – 479
Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.
Devlin A.M.; Ling E.-H.; Peerson J.M.; Fernando S.; Clarke R.; Smith A.D.; Halsted C.H.;
Hum. Mol. Genet. 9:2837-2844(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PSMA-1); VARIANT TYR-475; TISSUE SPECIFICITY;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.