Variant position: 469 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 911 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KIKPEYVSGLM---DELDILIVG GYWGKG--SRGGMMSHFLCAVA-----------------E
Mouse KIKPEYVSGLM---DELDVLIVG GYWGKG--SRGGMMSHFL
Chicken KIKPEYVNGLM---DELDLLIVG GYWGKG--SRGGMMSHFL
Slime mold KIKPEYIDGMGNGADDLDLVIIG GYYGSGLNRRGGTISHFM
Baker's yeast KVKPEYLEEFG---ENLDLIVIG --------RDSGKKDSFM
Fission yeast KVKPYYLQGFG---EDLDCLILG GYFGRG--KQSGKINSFL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency.
O'Driscoll M.; Cerosaletti K.M.; Girard P.-M.; Dai Y.; Stumm M.; Kysela B.; Hirsch B.; Gennery A.; Palmer S.E.; Seidel J.; Gatti R.A.; Varon R.; Oettinger M.A.; Neitzel H.; Jeggo P.A.; Concannon P.;
Mol. Cell 8:1175-1185(2001)
Cited for: VARIANTS LIG4S HIS-278 AND GLU-469;
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