Variant position: 662 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 756 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LIDNYVPPLEGLPIFILRLA TEV-NWDEEKECFESLSKECAM
Mouse LIDSYVPPLEGLPIFILRLA TEV-NWDEEKECFESLSKECA
Rat LIDSYVPPLEGLPIFILRLA TEV-NW-DEEECFESLSKECA
Slime mold VLDHYVPCTDNLPIFLLKLA TEV-EWEFEKECFAGIVKEIS
Baker's yeast LLKGYIPSLVKLPFFIYRLG KEV-DWEDEQECLDGILREIA
Fission yeast LSPKYHPPFEQLPLLISSLT PKFFDWLDEKSCLNGIMKAIA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 756 DNA mismatch repair protein Mlh1
653 – 662
Sixteen rare sequence variants of the hMLH1 and hMSH2 genes found in a cohort of 254 suspected HNPCC (hereditary non-polyposis colorectal cancer) patients: mutations or polymorphisms?
Mueller-Koch Y.; Kopp R.; Lohse P.; Baretton G.; Stoetzer A.; Aust D.; Daum J.; Kerker B.; Gross M.; Dietmeier W.; Holinski-Feder E.;
Eur. J. Med. Res. 6:473-482(2001)
Cited for: VARIANTS HNPCC2 VAL-80; PRO-329; ARG-603; ALA-618; LEU-648 AND PRO-662; VARIANT HNPCC ARG-689;
Seven novel MLH1 and MSH2 germline mutations in hereditary nonpolyposis colorectal cancer.
Krueger S.; Plaschke J.; Pistorius S.; Jeske B.; Haas S.; Kraemer H.; Hinterseher I.; Bier A.; Kreuz F.R.; Theissig F.; Saeger H.D.; Schackert H.K.;
Hum. Mutat. 19:82-82(2002)
Cited for: VARIANT HNPCC2 PRO-662; VARIANT VAL-219;
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