Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P17931: Variant p.Pro64His

Galectin-3
Gene: LGALS3
Feedback?
Variant information Variant position: help 64
Type of variant: help LB/B
Residue change: help From Proline (P) to Histidine (H) at position 64 (P64H, p.Pro64His).
Physico-chemical properties: help Change from medium size and hydrophobic (P) to medium size and polar (H)
BLOSUM score: help -2
Other resources: help


Sequence information Variant position: help 64
Protein sequence length: help 250
Location on the sequence: help AYPGQAPPGAYPGQAPPGAY P GAPGAYPGAPAPGVYPGPPS
Residue conservation: help 
Human                         AYPGQAPPGAYPGQAPPGAYPG-----------AP------------------GAYPGAPAPGVYPGP-----------------PS

                              AYPGQAPPGGYPGQAPPGGYPGQAPPGGYPGQAPPGGYPGQ

Mouse                         AYPGQAPPGAYPGQAPPGAYPGQAPPSAYPGPTAP------

Rat                           AYPGQAPPGGYPGQAPPSAYPGPTGPSAYPGPTAP------

Rabbit                        AYPGHA-PGAYPGQAPPGPYPG------------P------
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 250 Galectin-3
Repeat 63 – 69 4; approximate
Region 36 – 109 8 X 9 AA tandem repeats of Y-P-G-X(3)-P-G-A



Literature citations
Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms.
Robertson M.W.; Albrandt K.; Keller D.; Liu F.-T.;
Biochemistry 29:8093-8100(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS HIS-64 AND PRO-98; Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen.
Oda Y.; Leffler H.; Sakakura Y.; Kasai K.; Barondes S.H.;
Gene 99:279-283(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS HIS-64 AND PRO-98; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS HIS-64 AND PRO-98;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.