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UniProtKB/Swiss-Prot P17931: Variant p.Thr98Pro

Galectin-3
Gene: LGALS3
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Variant information Variant position: help 98
Type of variant: help LB/B
Residue change: help From Threonine (T) to Proline (P) at position 98 (T98P, p.Thr98Pro).
Physico-chemical properties: help Change from medium size and polar (T) to medium size and hydrophobic (P)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 98
Protein sequence length: help 250
Location on the sequence: help VYPGPPSGPGAYPSSGQPSA T GAYPATGPYGAPAGPLIVPY
Residue conservation: help 
Human                         VYPGP-----------------PSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPY

                              TYPGPTAPAYPGPTAPGTQPGQPSGPGAYPPPGQPSAPGAY

Mouse                         AYPGQ-------P-APGAFPGQPGAPGAY-----PQCSGGY

Rat                           AFPGQ-------PGGPGAY---PSAPGAY-----PSAPGAY

Rabbit                        AYPGQ-----------------PGGPGAYPSPGQPSGAGAY
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 250 Galectin-3
Repeat 89 – 100 7; approximate
Region 36 – 109 8 X 9 AA tandem repeats of Y-P-G-X(3)-P-G-A



Literature citations
Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms.
Robertson M.W.; Albrandt K.; Keller D.; Liu F.-T.;
Biochemistry 29:8093-8100(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS HIS-64 AND PRO-98; Molecular cloning of a human macrophage lectin specific for galactose.
Cherayil B.; Chaitovitz S.; Wong C.; Pillai S.;
Proc. Natl. Acad. Sci. U.S.A. 87:7324-7328(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT PRO-98; Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen.
Oda Y.; Leffler H.; Sakakura Y.; Kasai K.; Barondes S.H.;
Gene 99:279-283(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS HIS-64 AND PRO-98; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS HIS-64 AND PRO-98;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.