Variant position: 241 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 346 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human CEFDSQASAPRARHLQSLGA TLRELSSAFQSPVLCINQVTE
Mouse CEFHLQASAIRAKLLLSLGA TLRRLSSTFRSPVLCINQVTD
Bovine CEFDGAALALRAQRLLALGA ELRRLSCAFRSPVLCVNQVTE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 346 DNA repair protein XRCC3
XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.
Liu N.; Lamerdin J.E.; Tebbs R.S.; Schild D.; Tucker J.D.; Shen M.R.; Brookman K.W.; Siciliano M.J.; Walter C.A.; Fan W.; Narayana L.S.; Zhou Z.-Q.; Adamson A.W.; Sorensen K.J.; Chen D.J.; Jones N.J.; Thompson L.H.;
Mol. Cell 1:783-793(1998)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]; VARIANT MET-241;
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS HIS-94 AND MET-241;
A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.
Winsey S.L.; Haldar N.A.; Marsh H.P.; Bunce M.; Marshall S.E.; Harris A.L.; Wojnarowska F.; Welsh K.I.;
Cancer Res. 60:5612-5616(2000)
Cited for: VARIANT CMM6 MET-241;
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