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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q92956: Variant p.Lys17Arg

Tumor necrosis factor receptor superfamily member 14
Gene: TNFRSF14
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Variant information Variant position: help 17
Type of variant: help LB/B
Residue change: help From Lysine (K) to Arginine (R) at position 17 (K17R, p.Lys17Arg).
Physico-chemical properties: help Similar physico-chemical property. Both residues are large size and basic.
BLOSUM score: help 2
Other resources: help


Sequence information Variant position: help 17
Protein sequence length: help 283
Location on the sequence: help MEPPGDWGPPPWRSTP K TDVLRLVLYLTFLGAPCYAP
Residue conservation: help 
Human                         MEPPGDWGPPPWRSTPKTDVLRLVLYLTFLGAPCYAP

Mouse                         MEPLPGWGSAPWSQAPTDNTFRLVPCVFLLNLLQRIS
Sequence annotation in neighborhood: help
TypePositionsDescription
Signal peptide 1 – 38
Alternative sequence 1 – 100 MEPPGDWGPPPWRSTPKTDVLRLVLYLTFLGAPCYAPALPSCKEDEYPVGSECCPKCSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQMCD -> MVSRPPRTPLSPSSWT. In isoform 2.



Literature citations
Search for polymorphisms in the genes for herpesvirus entry mediator, Nectin-1, and Nectin-2 in immune seronegative individuals.
Struyf F.; Posavad C.M.; Keyaerts E.; Van Ranst M.; Corey L.; Spear P.G.;
J. Infect. Dis. 185:36-44(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS ARG-17 AND ILE-241; The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Clark H.F.; Gurney A.L.; Abaya E.; Baker K.; Baldwin D.T.; Brush J.; Chen J.; Chow B.; Chui C.; Crowley C.; Currell B.; Deuel B.; Dowd P.; Eaton D.; Foster J.S.; Grimaldi C.; Gu Q.; Hass P.E.; Heldens S.; Huang A.; Kim H.S.; Klimowski L.; Jin Y.; Johnson S.; Lee J.; Lewis L.; Liao D.; Mark M.R.; Robbie E.; Sanchez C.; Schoenfeld J.; Seshagiri S.; Simmons L.; Singh J.; Smith V.; Stinson J.; Vagts A.; Vandlen R.L.; Watanabe C.; Wieand D.; Woods K.; Xie M.-H.; Yansura D.G.; Yi S.; Yu G.; Yuan J.; Zhang M.; Zhang Z.; Goddard A.D.; Wood W.I.; Godowski P.J.; Gray A.M.;
Genome Res. 13:2265-2270(2003)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT ARG-17; Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ARG-17; THR-117; GLU-174 AND ILE-241;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.