Variant position: 20 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 114 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MTCKM-SQLERNIETIINTF HQYSVKLGHPDTLNQGEFKEL
Mouse MANKAPSQMERSITTIIDTF HQYSRKEGHPDTLSKKEFRQ
Rat MAAKTGSQLERSISTIINVF HQYSRKYGHPDTLNKAEFKE
Bovine MEDKM-SQMESSIETIINIF HQYSVRLGHYDTLIQKEFKQ
Rabbit MSCGM-SQLERSIDTIINVF HQYSVRVGPRDSLSQKEFKQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 114 Protein S100-A9
12 – 47 EF-hand 1
20 – 20 Zinc
23 – 23 Calcium 1; via carbonyl oxygen; low affinity
26 – 26 Calcium 1; via carbonyl oxygen; low affinity
28 – 28 Calcium 1; via carbonyl oxygen; low affinity
30 – 30 Zinc
31 – 31 Calcium 1; via carbonyl oxygen; low affinity
36 – 36 Calcium 1; low affinity
2 – 2 Blocked amino end (Thr)
3 – 3 S-nitrosocysteine; transient
3 – 3 C -> A. Disrupts interaction with NOS2 and inhibits LDL(ox)-induced GAPDH S-nitrosylation; no effect on interaction with S100A8.
36 – 36 E -> Q. Loss of resistance to bacterial invasion; when associated with Q-78.
7 – 23
Human gene for migration inhibitory factor-related protein 14 (MRP14), variant allele.
Wang M.; Xu X.; Cai Y.; Xu H.; Han Y.; Xu Z.; Wu M.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT ARG-20;
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