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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P02675: Variant p.Pro100Ser

Fibrinogen beta chain
Gene: FGB
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Variant information Variant position: help 100
Type of variant: help LB/B
Residue change: help From Proline (P) to Serine (S) at position 100 (P100S, p.Pro100Ser).
Physico-chemical properties: help Change from medium size and hydrophobic (P) to small size and polar (S)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 100
Protein sequence length: help 491
Location on the sequence: help ATQKKVERKAPDAGGCLHAD P DLGVLCPTGCQLQEALLQQE
Residue conservation: help 
Human                         ATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQE

Mouse                         ANQKKVERRPPDAGGCLHADTDMGVLCPTGCTLQQTLLNQE

Rat                           AGQKKVERKPPDAGGCVHGDGDMGVLCPTGCELRQTLLNHE

Bovine                        VGQKKVERKPPDADGCLHADPDLGVLCPTGCKLQDTLVRQE
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 45 – 491 Fibrinogen beta chain
Disulfide bond 95 – 95 Interchain (with C-55 in alpha chain)
Disulfide bond 106 – 106 Interchain (with C-68 in alpha chain)
Disulfide bond 110 – 110 Interchain (with C-45 in gamma chain)
Turn 100 – 102



Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS SER-100; HIS-170; LEU-265 AND LYS-478;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.