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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P22891: Variant p.Glu70Lys

Vitamin K-dependent protein Z
Gene: PROZ
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Variant information Variant position: help 70
Type of variant: help LB/B
Residue change: help From Glutamate (E) to Lysine (K) at position 70 (E70K, p.Glu70Lys).
Physico-chemical properties: help Change from medium size and acidic (E) to large size and basic (K)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 70
Protein sequence length: help 400
Location on the sequence: help FEGNLEKECYEEICVYEEAR E VFENEVVTDEFWRRYKGGSP
Residue conservation: help 
Human                         FEGNLEKECYEEICVYEEAREVFENEVVTDEFWRRYKGGSP

Mouse                         FQGNLEKECYEEVCNYEEAREVFENDVITDEFWRQYGGGSP

Bovine                        FEGHLEKECWEEICVYEEAREVFEDDETTDEFWRTYMGGSP
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 41 – 400 Vitamin K-dependent protein Z
Domain 41 – 86 Gla
Modified residue 51 – 51 4-carboxyglutamate
Modified residue 55 – 55 4-carboxyglutamate
Modified residue 57 – 57 4-carboxyglutamate
Modified residue 60 – 60 4-carboxyglutamate
Modified residue 61 – 61 4-carboxyglutamate
Modified residue 66 – 66 4-carboxyglutamate
Modified residue 67 – 67 4-carboxyglutamate
Modified residue 70 – 70 4-carboxyglutamate
Modified residue 73 – 73 4-carboxyglutamate
Modified residue 75 – 75 4-carboxyglutamate
Modified residue 80 – 80 4-carboxyglutamate



Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS LYS-70 AND HIS-295;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.