Variant position: 845 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 934 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SFGIHVAELANFPKHVIECA KQKALELEEFQYIGESQGYDI
Mouse SFGIHVAELANFPRHVIACA KQKALELEEFQNIGTSLGCDE
Rat SFGIHVAELANFPRHVIECA KQKALELEEFQSIGTSQGHDE
Bovine SFGIHVAELANFPRHVIECA KQKALELEEFQNIGKPQECDE
Drosophila SFGIQVARLANFPEHVVQNA QEVYNEFED-EHVDKQKKEDK
Slime mold SFGIHVAILANFPSQVIENA KQKAKELESFESNTLKQNHNK
Baker's yeast SFGIHVAEVVQFPEKIVKMA KRKANELDDLKTNNEDLKKAK
Fission yeast SFGIHVAKLAHFPPKIIEMA SNKAAELEA-EDSGAQGDTQE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 934 DNA mismatch repair protein Msh2
838 – 850
Enhanced detection of deleterious and other germline mutations of hMSH2 and hMLH1 in Japanese hereditary nonpolyposis colorectal cancer kindreds.
Nomura S.; Sugano K.; Kashiwabara H.; Taniguchi T.; Fukayama N.; Fujita S.; Akasu T.; Moriya Y.; Ohhigashi S.; Kakizoe T.; Sekiya T.;
Biochem. Biophys. Res. Commun. 271:120-129(2000)
Cited for: VARIANTS HNPCC1 ILE-688 AND GLU-845; VARIANT MET-8;
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