Variant position: 152 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 735 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FNWKLFWQFLHPHLLVLGVA VVLALGAALVNVQIPLLLGQL
Mouse FNWKLFWHFLHPHLLALGAA IVLALGAALVNVQIPLLLGQL
Rat FKWKLFWHFLHPHLLALGLA IVLALGAALVNVQIPLLLGQL
Xenopus tropicalis FNWAEFWKLLRPQLIALLTA VLLAFGAALLNIRIPLMLGEL
Zebrafish FSWAVLWEFVRPQLFALMGA ILLAFGAAALNIQIPLMLGDL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
26 – 735 Mitochondrial potassium channel ATP-binding subunit
145 – 165 Helical
150 – 437 ABC transmembrane type-1
1 – 187 Missing. In isoform 5.
1 – 153 MLVHLFRVGIRGGPFPGRLLPPLRFQTFSAVRNTWRNGKTGQLHKAEGEYSDGYRSSSLLRAVAHLRSQLWAHLPRAPLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVV -> MRVKLLLPAAPVLPRQHAGAFISGRDSGWPIPRQAATAPPLPDILSCQ. In isoform 4.
145 – 171
Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population.
Saito S.; Iida A.; Sekine A.; Miura Y.; Ogawa C.; Kawauchi S.; Higuchi S.; Nakamura Y.;
J. Hum. Genet. 47:38-50(2002)
Cited for: VARIANT ILE-152;
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