Variant position: 138 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 769 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TFRRAKGYPIDLYYLMDLSY SMLDDLRNVKKLGGDLLRALN
Mouse TFRRAKGYPIDLYYLMDLSY SMLDDLNNVKKLGGDLLQALN
Pig TFRRAKGYPIDLYYLMDLSY SMLDDLINVKKLGGDLLRALN
Bovine TFRRAKGYPIDLYYLMDLSY SMVDDLVNVKKLGGDLLRALN
Goat TFQRAKGYPIDLYYLMDLSY SMVDDLANVKKLGGDLLRALN
Sheep TFQRAKGYPIDLYYLMDLSY SMVDDLANVKKLGGDLLRALN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1.
Hogg N.; Stewart M.P.; Scarth S.L.; Newton R.; Shaw J.M.; Law S.K.A.; Klein N.;
J. Clin. Invest. 103:97-106(1999)
Cited for: VARIANTS LAD1 PRO-138 AND ARG-273;
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