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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P23219: Variant p.Trp8Arg

Prostaglandin G/H synthase 1
Gene: PTGS1
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Variant information Variant position: help 8
Type of variant: help LB/B
Residue change: help From Tryptophan (W) to Arginine (R) at position 8 (W8R, p.Trp8Arg).
Physico-chemical properties: help Change from large size and aromatic (W) to large size and basic (R)
BLOSUM score: help -3
Other resources: help


Sequence information Variant position: help 8
Protein sequence length: help 599
Location on the sequence: help MSRSLLL W FLLFLLLLPPLPVLLADPGA
Residue conservation: help
Human                         MSR-SLLLWFLLFLLLL------PPLPVLLADPGA

                              MSRGSRLHRWPLLLLLLLLL---PPPPV

Mouse                         MSRRSLSLWFPLLLLLLLP----PTPSV

Rat                           MSRRSLSLQFPLLLLLLLL----PPPPV

Bovine                        MSRQGISLRFPLLLLLL------SPSPV

Rabbit                        MSRSSPSLRLPVLLLLLLLLLLPPPPPV

Sheep                         MSRQSISLRFPLLLLLL------SPSPV

Sequence annotation in neighborhood: help
TypePositionsDescription
Signal peptide 1 – 23
Alternative sequence 1 – 109 Missing. In isoform 4.
Alternative sequence 1 – 32 MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPV -> MRKPRLM. In isoform 3.



Literature citations
Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme.
Yokoyama C.; Tanabe T.;
Biochem. Biophys. Res. Commun. 165:888-894(1989)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1); VARIANT ARG-8; Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment.
Funk C.D.; Funk L.B.; Kennedy M.E.; Pong A.S.; Fitzgerald G.A.;
FASEB J. 5:2304-2312(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); MUTAGENESIS OF SER-529; VARIANT ARG-8; Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase).
Takahashi Y.; Ueda N.; Yoshimoto T.; Yamamoto S.; Yokoyama C.; Miyata A.; Tanabe T.; Fuse I.; Hattori A.; Shibata A.;
Biochem. Biophys. Res. Commun. 182:433-438(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT ARG-8; Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha.
Diaz A.; Reginato A.M.; Jimenez S.A.;
J. Biol. Chem. 267:10816-10822(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); VARIANT ARG-8; Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis.
Scott B.T.; Hasstedt S.J.; Bovill E.G.; Callas P.W.; Valliere J.E.; Wang L.-H.; Wu K.K.; Long G.L.;
Blood Coagul. Fibrinolysis 13:519-531(2002)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1); VARIANTS ARG-8 AND LEU-17; Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T.; Suzuki Y.; Nishikawa T.; Otsuki T.; Sugiyama T.; Irie R.; Wakamatsu A.; Hayashi K.; Sato H.; Nagai K.; Kimura K.; Makita H.; Sekine M.; Obayashi M.; Nishi T.; Shibahara T.; Tanaka T.; Ishii S.; Yamamoto J.; Saito K.; Kawai Y.; Isono Y.; Nakamura Y.; Nagahari K.; Murakami K.; Yasuda T.; Iwayanagi T.; Wagatsuma M.; Shiratori A.; Sudo H.; Hosoiri T.; Kaku Y.; Kodaira H.; Kondo H.; Sugawara M.; Takahashi M.; Kanda K.; Yokoi T.; Furuya T.; Kikkawa E.; Omura Y.; Abe K.; Kamihara K.; Katsuta N.; Sato K.; Tanikawa M.; Yamazaki M.; Ninomiya K.; Ishibashi T.; Yamashita H.; Murakawa K.; Fujimori K.; Tanai H.; Kimata M.; Watanabe M.; Hiraoka S.; Chiba Y.; Ishida S.; Ono Y.; Takiguchi S.; Watanabe S.; Yosida M.; Hotuta T.; Kusano J.; Kanehori K.; Takahashi-Fujii A.; Hara H.; Tanase T.-O.; Nomura Y.; Togiya S.; Komai F.; Hara R.; Takeuchi K.; Arita M.; Imose N.; Musashino K.; Yuuki H.; Oshima A.; Sasaki N.; Aotsuka S.; Yoshikawa Y.; Matsunawa H.; Ichihara T.; Shiohata N.; Sano S.; Moriya S.; Momiyama H.; Satoh N.; Takami S.; Terashima Y.; Suzuki O.; Nakagawa S.; Senoh A.; Mizoguchi H.; Goto Y.; Shimizu F.; Wakebe H.; Hishigaki H.; Watanabe T.; Sugiyama A.; Takemoto M.; Kawakami B.; Yamazaki M.; Watanabe K.; Kumagai A.; Itakura S.; Fukuzumi Y.; Fujimori Y.; Komiyama M.; Tashiro H.; Tanigami A.; Fujiwara T.; Ono T.; Yamada K.; Fujii Y.; Ozaki K.; Hirao M.; Ohmori Y.; Kawabata A.; Hikiji T.; Kobatake N.; Inagaki H.; Ikema Y.; Okamoto S.; Okitani R.; Kawakami T.; Noguchi S.; Itoh T.; Shigeta K.; Senba T.; Matsumura K.; Nakajima Y.; Mizuno T.; Morinaga M.; Sasaki M.; Togashi T.; Oyama M.; Hata H.; Watanabe M.; Komatsu T.; Mizushima-Sugano J.; Satoh T.; Shirai Y.; Takahashi Y.; Nakagawa K.; Okumura K.; Nagase T.; Nomura N.; Kikuchi H.; Masuho Y.; Yamashita R.; Nakai K.; Yada T.; Nakamura Y.; Ohara O.; Isogai T.; Sugano S.;
Nat. Genet. 36:40-45(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4); VARIANT ARG-8; Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1); VARIANTS ARG-8; LEU-17; HIS-53; LEU-149 AND MET-237; Submission
Mural R.J.; Istrail S.; Sutton G.G.; Florea L.; Halpern A.L.; Mobarry C.M.; Lippert R.; Walenz B.; Shatkay H.; Dew I.; Miller J.R.; Flanigan M.J.; Edwards N.J.; Bolanos R.; Fasulo D.; Halldorsson B.V.; Hannenhalli S.; Turner R.; Yooseph S.; Lu F.; Nusskern D.R.; Shue B.C.; Zheng X.H.; Zhong F.; Delcher A.L.; Huson D.H.; Kravitz S.A.; Mouchard L.; Reinert K.; Remington K.A.; Clark A.G.; Waterman M.S.; Eichler E.E.; Adams M.D.; Hunkapiller M.W.; Myers E.W.; Venter J.C.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]; VARIANT ARG-8; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT ARG-8;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.