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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P55317: Variant p.Ala83Thr

Hepatocyte nuclear factor 3-alpha
Gene: FOXA1
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Variant information Variant position: help 83
Type of variant: help LB/B
Residue change: help From Alanine (A) to Threonine (T) at position 83 (A83T, p.Ala83Thr).
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and polar (T)
BLOSUM score: help 0
Other resources: help


Sequence information Variant position: help 83
Protein sequence length: help 472
Location on the sequence: help SFNMSYANPGLGAGLSPGAV A GMPGGSAGAMNSMTAAGVTA
Residue conservation: help 
Human                         SFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTA

Mouse                         SFNMSYANTGLGAGLSPGAVAGMPGASAGAMNSMTAAGVTA

Rat                           SFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTA

Xenopus tropicalis            SFNMSYANSGLGAGLSPSGMSGMGAGSASAMNGM-GSGVSS
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 472 Hepatocyte nuclear factor 3-alpha



Literature citations
The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.
Navas M.A.; Vaisse C.; Boger S.; Heimesaat M.; Kollee L.A.; Stoffel M.;
Hum. Hered. 50:370-381(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ALA-72; THR-83; MET-124 INS; ARG-185 AND ASN-448;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.