Variant position: 353 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 509 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GIKLTINKLLDMAAQIAEGM AFIEERNYIHRDLRAANILVS
Mouse GIKLNVNKLLDMAAQIAEGM AFIEEQNYIHRDLRAANILVS
Rat GIKLNVNKLLDMAAQIAEGM AFIEEQNYIHRDLRAANILVS
Chicken GIKLSINKLLDMAAQIAEGM AFIEAKNYIHRDLRAANILVS
Drosophila -------------------- ----------RDEKRNSVVLG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 509 Tyrosine-protein kinase Lck
245 – 498 Protein kinase
364 – 364 Proton acceptor
348 – 363 IAEGMAFIEERNYIHR -> VRRLGRGAGQGNRPVT. In isoform Short.
338 – 357
Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia.
Wright D.D.; Sefton B.M.; Kamps M.P.;
Mol. Cell. Biol. 14:2429-2437(1994)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS LEU-28; GLN-LYS-PRO-232 INS; VAL-353 AND LEU-447; PHOSPHORYLATION AT TYR-394 AND TYR-505;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.