Variant position: 406 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 741 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KQEVAVKTFCEGSPRAQREV SCLQSSRENSHLVTFYGSESH
Mouse NREVAVKVFRENSPRGCKEV SCLRDCGDHSNLVAFYGREDD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 741 2-5A-dependent ribonuclease
365 – 586 Protein kinase
395 – 444 C6-type; atypical
392 – 392 K -> R. Complete loss of enzymatic activity and enzyme dimerization. No change in binding to 2-5A and RNA.
399 – 409
Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer.
Roekman A.; Ikonen T.; Seppaelae E.H.; Nupponen N.; Autio V.; Mononen N.; Bailey-Wilson J.; Trent J.; Carpten J.; Matikainen M.P.; Koivisto P.A.; Tammela T.L.J.; Kallioniemi O.-P.; Schleutker J.;
Am. J. Hum. Genet. 70:1299-1304(2002)
Cited for: VARIANTS SER-59; PHE-406; GLN-462 AND GLU-541;
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