Sequence information
Variant position: 393 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 437 The length of the canonical sequence.
Location on the sequence:
RLSPLVAADSLLEHVREDFS
G LLPEEFISLSPPHEALDYHF
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RLSP---------------LVAADSLLEHVREDFSG LLPEE--FISLSPPHEALDYHF
Mouse QLSP---------------LVAADSLLEHVKEDFSG LLPGE
Rat RLSP---------------LVAADSLLEHVKEDFSG LLPGE
Chicken SLSP---------------LASMDTLLEHGKDDFPG FLADE
Drosophila SLPPGVADCDANSNSSSVTLQGLDALFNDIGSDY-- -FSND
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 437
Transcription factor E2F1
Region
368 – 437
Transactivation
Modified residue
375 – 375
Phosphoserine
Modified residue
403 – 403
Phosphoserine; by GSK3-beta
Mutagenesis
403 – 403
S -> A. Decreased phosphorylation by GSK3B, leading to abolished interaction with USP11 and subsequent deubiquitination.
Mutagenesis
411 – 411
Y -> C. No retinoblastoma protein binding. No effect on interaction with and repression of CEBPA.
Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS HIS-252; MET-276; ASN-311 AND SER-393;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.