Variant position: 334 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2224 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KHLQAGMQAYIDIKNCPKKT RNLKKITREQRRHMKRWEYFI
Mouse KHYQAGMQAYIDIKNCPKKT RSPKTLTREQRRYMKRWEYFI
Pig KHFQAGMQAYIDIKNCAKKT RKPKKLTRDQRRHIKRWEYFI
Bovine RHFQAGMQAYIDIKNCAKKT RNPKKLTRDQRRHIKRWEYFI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
29 – 2224 Coagulation factor V
29 – 737 Coagulation factor V heavy chain
334 – 335 Cleavage; by activated protein C
Factor V Cambridge: a new mutation (Arg306-to-Thr) associated with resistance to activated protein C.
Williamson D.; Brown K.; Luddington R.; Baglin C.; Baglin T.;
Cited for: VARIANT THPH2 THR-334;
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