Variant position: 89 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 325 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AGGAGLAM-----ALHSA-VSASDLE LHPPSYPWSHRGLLSSLDHTS
Mouse AGGAGLAV-----ALHSA-VSASDLE LHPPSYPWSHRGLLS
Bovine AGGAGLAV-----ALHSA-VSASDLE LHPPSYPWSHRGLLS
Slime mold SGVVGTAT-----AITTSTTLLSDDF VQPTSYPWEHRFPWQ
Baker's yeast AGITASTL-LYADSLTAEAMTAAEHG LHAPAYAWSHNGPFE
Fission yeast VGMIALYYNVYGPSLSAG--TPKEEG LHFIQHDWPQSKVLS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
85 – 325 Cytochrome c1, heme protein, mitochondrial
85 – 281 Mitochondrial intermembrane
Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1.
Nishikimi M.; Ohta S.; Suzuki H.; Tanaka T.; Kikkawa F.; Tanaka M.; Kagawa Y.; Ozawa T.;
Nucleic Acids Res. 16:3577-3577(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS VAL-76 AND VAL-89;
A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency.
Valnot I.; Kassis J.; Chretien D.; de Lonlay P.; Parfait B.; Munnich A.; Kachaner J.; Rustin P.; Roetig A.;
Hum. Genet. 104:460-466(1999)
Cited for: VARIANT VAL-89;
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