Sequence information
Variant position: 324 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 486 The length of the canonical sequence.
Location on the sequence:
WSADLNRTLSRREKKKATDG
V TLTGINQTGDQSLPSKPSST
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WSADLNRTLSRREKKKATDGV TLTGINQTGDQ-SLPSKPSST
Mouse WSADLNRTLSRREKKKAVDGV TLTGINQTGDQ-SGQNKPGS
Rat WSADLNRTLSRREKKKAADGV TLTGINQTGDQ-SGQNKPSS
Chicken WSADLNRTLSRREKKKASDGV TLTGINQTGDQVSQPNKHSS
Xenopus laevis WSADLNRTLSRREKKKPTDGV TLTGISQSGEQSSIQNQHSS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 486
Protein kinase C and casein kinase substrate in neurons protein 2
Region
1 – 362
(Microbial infection) Interaction with HCV NS5A
Region
314 – 426
Disordered
Compositional bias
324 – 368
Polar residues
Modified residue
313 – 313
Phosphoserine; by PKC
Mutagenesis
313 – 313
S -> A. Increased protein interaction with HCV NS5A.
Mutagenesis
313 – 313
S -> E. Decreased protein interaction with HCV NS5A.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.