Sequence information
Variant position: 356 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 565 The length of the canonical sequence.
Location on the sequence:
TPSGQITTSGALTFDRASTV
E ATAVISESPAQGDVFAGATV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TPSGQITTSGALTFDRASTVE ATAVISESPA----QGDVFAGATV
Chimpanzee TPSGQITTSGALTFDRASTVE ATAVISESPA----QGDVFA
Mouse TPSGQITTSGALTFDRASTVE ATAVISESPA----QGDVFA
Rat TPSGQITTSGALTFDRASTVE ATAVISESPA----QGDVFA
Drosophila TNNNNTSGSGA-----NNCVD VTAAVAAATASVVDENNMFL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 565
Deformed epidermal autoregulatory factor 1 homolog
Literature citations
Altered subcellular localization of suppressin, a novel inhibitor of cell-cycle entry, is an independent prognostic factor in colorectal adenocarcinomas.
Manne U.; Gary B.D.; Oelschlager D.K.; Weiss H.L.; Frost A.R.; Grizzle W.E.;
Clin. Cancer Res. 7:3495-3503(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3); VARIANTS VAL-186; ASN-191; ILE-191; 199-CYS-ASP-ASN-ASP-202; ASP-202; LYS-218; 350-GLY-GLN-THR-352; HIS-356; ASN-364; HIS-367; LEU-370; PHE-397; ALA-442; LYS-449; 451-GLY-ILE-452; HIS-468; LEU-479; LYS-498; ASN-526; LEU-530; 537-HIS-LEU-538; HIS-542; GLY-545 AND VAL-545; ROLE IN NEOPLASIA;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.