Sequence information
Variant position: 279 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 707 The length of the canonical sequence.
Location on the sequence:
TANYDTDDRFGFCPSERLYT
Q DGNADGKPCQFPFIFQGQSY
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TANYDTDDRFGFCPSERLYTQ DGNADGKPCQFPFIFQGQSY
TADYDTDRRFGFCPSEKLYAQ DGNGDGKPCVFPFTFEGRSY
Mouse TADYDKDGKFGFCPSERLYTE HGNGEGKPCVFPFIFEGRSY
Rat TADYDTDRKYGFCPSENLYTE HGNGDGKPCVFPFIFEGHSY
Bovine TADYDADRQFGFCPSERLYTQ DGNADGKPCVFPFTFQGRTY
Rabbit TADYDTDRRFGFCPSERLYTQ DGNADGKPCEFPFIFQGRTY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
107 – 707
82 kDa matrix metalloproteinase-9
Beta strand
279 – 283
Literature citations
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.
Wilhelm S.M.; Collier I.E.; Marmer B.L.; Eisen A.Z.; Grant G.A.; Goldberg G.I.;
J. Biol. Chem. 264:17213-17221(1989)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; PROTEIN SEQUENCE OF 20-37; SUBCELLULAR LOCATION; VARIANTS ARG-279 AND PRO-574;
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-20; LYS-127; ARG-279; PRO-574 AND GLN-668;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS ARG-279 AND PRO-574;
Genetic variation at the matrix metalloproteinase-9 locus on chromosome 20q12.2-13.1.
Zhang B.; Henney A.; Eriksson P.; Hamsten A.; Watkins H.; Ye S.;
Hum. Genet. 105:418-423(1999)
Cited for: VARIANTS VAL-20; LYS-82 AND ARG-279;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.