Variant position: 455 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 911 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MGVSELLISTAVQGILFALL GAQPLLVVGFSGPLLVFEEAF
Mouse MGVSELLISTAVQGILFALL GAQPLLVLGFSGPLLVFEEAF
Rat MGVSELLISTAVQGILFALL GAQPLLVLGFSGPLLVFEEAF
Chicken MGVSELLLSTSVQCLLFSLL SAQPLLVVGFSGPLLVFEEAF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 911 Band 3 anion transport protein
436 – 456 Helical; Name=2
Characterization of 13 novel band 3 gene defects in hereditary spherocytosis with band 3 deficiency.
Jarolim P.; Murray J.L.; Rubin H.L.; Taylor W.M.; Prchal J.T.; Ballas S.K.; Snyder L.M.; Chrobak L.; Melrose W.D.; Brabec V.; Palek J.;
Cited for: VARIANTS SPH4 ASP-285; GLU-455; PRO-707; PRO-834 AND MET-837;
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