Variant position: 808 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 911 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LFGIFLYMGVTSLSGIQLFD RILLLFKPPKYHPDVPYVKRV
Mouse LFGIFLYMGVTSLSGIQLFD RILLLFKPPKYHPDVPFVKRV
Rat LFGIFLYMGITSLSGIQLFD RILLLFKPPKYHPDVPFVKRV
Chicken LFGIFLYMGVTSLFGIQLFD RILLLLMPPKYHPKEPYVTRV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 911 Band 3 anion transport protein
801 – 838 Cytoplasmic
804 – 813
Mutations of conserved arginines in the membrane domain of erythroid band 3 lead to a decrease in membrane-associated band 3 and to the phenotype of hereditary spherocytosis.
Jarolim P.; Rubin H.L.; Brabec V.; Chrobak L.; Zolotarev A.S.; Alper S.L.; Brugnara C.; Wichterle H.; Palek J.;
Cited for: VARIANTS SPH4 GLN-760; TRP-760; CYS-808 AND TRP-870;
Trafficking and folding defects in hereditary spherocytosis mutants of the human red cell anion exchanger.
Quilty J.A.; Reithmeier R.A.;
Cited for: CHARACTERIZATION OF VARIANTS PRO-707; GLN-760; TRP-760; CYS-808; PRO-834; MET-837 AND TRP-870;
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