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UniProtKB/Swiss-Prot Q16667: Variant p.Trp31Arg

Cyclin-dependent kinase inhibitor 3
Gene: CDKN3
Variant information

Variant position:  31
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LP/P [Disclaimer]
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Tryptophan (W) to Arginine (R) at position 31 (W31R, p.Trp31Arg).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and aromatic (W) to large size and basic (R)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -3
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In HCC; patient BX-01.
Any additional useful information about the variant.



Sequence information

Variant position:  31
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  212
The length of the canonical sequence.

Location on the sequence:   EFDSSDEEPIEDEQTPIHIS  W LSLSRVNCSQFLGLCALPGC
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         EFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGC

Mouse                         EFDSSDEEPVDEEQTPIQISWLPLSRVNCSQFLGLCALPGC

Rat                           EFDSSDEEPADDEQTPIQISWLPLSRVNCSQFLGLCALPGC

Pig                           EFDSSDEEPIEDEQTPIQISWLPLSRVNYSQFLGLCALPGC

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 212 Cyclin-dependent kinase inhibitor 3
Region 1 – 34 Interaction with CDK2
Alternative sequence 11 – 50 Missing. In isoform 2.
Beta strand 30 – 33


Literature citations

Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma.
Yeh C.-T.; Lu S.-C.; Chen T.-C.; Peng C.-Y.; Liaw Y.-F.;
Cancer Res. 60:4697-4700(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); VARIANTS HCC ARG-31; LEU-78; TYR-79; LYS-91; VAL-94; PHE-95; VAL-108; SER-187 AND ILE-195;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.