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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q16667: Variant p.Lys195Ile

Cyclin-dependent kinase inhibitor 3
Gene: CDKN3
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Variant information Variant position: help 195 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Lysine (K) to Isoleucine (I) at position 195 (K195I, p.Lys195Ile). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and basic (K) to medium size and hydrophobic (I) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In HCC; patient NT4. Any additional useful information about the variant.


Sequence information Variant position: help 195 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 212 The length of the canonical sequence.
Location on the sequence: help RGSGAIQTIKQYNYLHEFRD K LAAHLSSRDSQSRSVSR The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         RGSGAIQTIKQYNYLHEFRDKLAAHLSSRDSQSRSVSR

Mouse                         RGSGAIQTIKQYNYLHEFRDKLAAYLSSRDSLSRSVSR

Rat                           RGSGAIQTIKQYNYLHEFRDKLAAYLSSRDSLSRSVSR

Pig                           RGSGAIQTIKQYNYLHEFRDKLAAHLSSRESLSRSVSR
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 212 Cyclin-dependent kinase inhibitor 3
Domain 33 – 201 Tyrosine-protein phosphatase
Helix 192 – 197



Literature citations
Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma.
Yeh C.-T.; Lu S.-C.; Chen T.-C.; Peng C.-Y.; Liaw Y.-F.;
Cancer Res. 60:4697-4700(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); VARIANTS HCC ARG-31; LEU-78; TYR-79; LYS-91; VAL-94; PHE-95; VAL-108; SER-187 AND ILE-195;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.