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UniProtKB/Swiss-Prot P21964: Variant p.Cys34Ser

Catechol O-methyltransferase
Gene: COMT
Variant information

Variant position:  34
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Cysteine (C) to Serine (S) at position 34 (C34S, p.Cys34Ser).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and polar (C) to small size and polar (S)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Polymorphism:  Two alleles, COMT*1 or COMT*H with Val-158 and COMT*2 or COMT*L with Met-158 are responsible for a three to four-fold difference in enzymatic activity.Low enzyme activity alleles are associated with genetic susceptibility to alcoholism [MIM:103780]. -
Additional information on the polymorphism described.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  34
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  271
The length of the canonical sequence.

Location on the sequence:   LGLVLLVVLLLLLRHWGWGL  C LIGWNEFILQPIHNLLMGDT
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         LGLVLLVVLLLL----LRHWGWGLCLIGWNEFILQPIHNLLMGDT

Mouse                         LGLLLLA-FLLL----LRHLGWGLVAIGWFEFVQQPVHNLL

Rat                           LGLLLLA-LLLL----LRHLGWGLVTIFWFEYVLQPVHNLI

Bovine                        VGLALLA-LRWLATTDLQFFGRAFIV--WNEFIMKPIRNLL

Horse                         LGLALLP-LLFF----LRRWGWLLIG--WNECILQPIHNLL

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 271 Catechol O-methyltransferase
Topological domain 27 – 271 Extracellular
Alternative sequence 1 – 50 Missing. In isoform Soluble.


Literature citations

Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form.
Bertocci B.; Miggiano V.; da Prada M.; Dembic Z.; Lahm H.-W.; Malherbe P.;
Proc. Natl. Acad. Sci. U.S.A. 88:1416-1420(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT SER-34;

Characterization of single-nucleotide polymorphisms in coding regions of human genes.
Cargill M.; Altshuler D.; Ireland J.; Sklar P.; Ardlie K.; Patil N.; Shaw N.; Lane C.R.; Lim E.P.; Kalyanaraman N.; Nemesh J.; Ziaugra L.; Friedland L.; Rolfe A.; Warrington J.; Lipshutz R.; Daley G.Q.; Lander E.S.;
Nat. Genet. 22:231-238(1999)
Cited for: VARIANTS SER-34 AND SER-72;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.