Variant position: 72 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 160 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IAMRAINNYRWRCKNQNTFL RTTFANVVNVCGNQSIRCPHN
Gorilla IAMRVINNYRWRCKNQNTFL RTTFANVVNVCGNQSIRCLHN
Chimpanzee IAMRVINNYRWRCKNQNTFL RTTFANVVNVCGNQSIRCPHN
Rat DAMRHRNRFTGHCKDINTFL HTSFASVVGVCGNRNIPC-GN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
28 – 160 Eosinophil cationic protein
28 – 72 Required for nearly all of the bactericidal activity; partially involved in LPS-binding and bacterial membrane depolarization
60 – 60 May be involved in LPS-binding
62 – 62 May be involved in LPS- and LTA-binding
60 – 60 3'-nitrotyrosine
84 – 84 N-linked (GlcNAc...) asparagine
92 – 92 N-linked (GlcNAc...) asparagine
50 – 110
64 – 123
66 – 73
Identification of polymorphisms in the ECP gene. Relation to disease activity in Hodgkins lymphoma.
Bystrom J.; Molin D.; Jonsson U.B.; Enblad G.; Sundstrom C.; Hogbom E.; Venge P.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-160; VARIANTS CYS-72 AND ARG-124;
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